Human Metapneumovirus (HMPV) Binding and Infection Are Mediated by Interactions between the HMPV Fusion Protein and Heparan Sulfate

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Human Metapneumovirus Binding and Infection is Mediated 1 by Interactions between the HMPV Fusion Protein and 2 Heparan Sulfate 3

23 Human metapneumovirus (HMPV) is a major worldwide respiratory pathogen that causes acute upper 24 and lower respiratory tract disease. The mechanism by which this virus recognizes and gains access to its 25 target cell is still largely unknown. In this study, we addressed the initial steps in virus binding and 26 infection and found that the first binding partner for HMPV is heparan sulfate ...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2012

ISSN: 0022-538X

DOI: 10.1128/jvi.06706-11